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Main Research

We are a translational research team, investigating the underlying disease mechanisms of obesity and cardiometabolic disease, with a special interest in inflammatory resolution.

Inflammation is a key driver of obesity-induced cardiometabolic pathophysiology and consists of two phases: an initial acute phase followed by a resolving phase. The latter is actively regulated by specialized pro-resolving lipid mediators (SPMs). Lipoxins are one group of SPMs that act through defined receptors to promote resolution of inflammation.

The overall aim of our research is to investigate and harness the therapeutic potential of lipoxins. Our studies suggest that treatment with lipoxins attenuates obesity-induced adipose inflammation and subsequent development of systemic disease (Börgeson et al, Cell Metabolism, 2015). We are currently investigating the underlying mechanisms that mediate this protection, and whether our results from preclinical models can be translated to human pathophysiology.

We combine experimental studies with clinical basic research to address our hypotheses in a translational manner. We use ex vivo culture of tissue biopsies, which provide valuable “proof-of-principle” evidence to correlate our experimental data with human physiology. This translational approach requires state-of-the art experimental and clinical facilities, as well as a broad network of expertise, made possible via our collaborators. For more information on our research, please visit Borgeson lab.

Contact Information

Emma Börgeson

Wallenberglaboratoriet, Sahlgrenska University Hospital Blå Stråket 5, 413 45, Gothenburg

Visiting Address:
Sahlgrenska University Hospital Blå Stråket 5, Elevator H, level 2/3

Delivery address:
Wallenberglaboratoriet, Lab 7, Bruna Stråket 16, 413 45 Göteborg, Sweden

+46 31 342 38 33 (office)
+46 31 342 94 83 (lab)
+46 70 285 52 82 (cell)

+46 31 82 37 62

Page Manager: Anna Hallén|Last update: 3/21/2017

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