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Main research

Our research is focused on atherothrombosis - mechanisms responsible for thrombotic vessel occlusions that cause myocardial infarction and ischemic stroke.

In early studies the group showed that in normal blood vessels the clinical outcome of a sudden intravascular clotting depends on whether the endogenous thromboprotective defense system can dissolve the clot before tissue damage occurs. In subsequent work it was found that some cardiovascular risk factors impair this function by suppressing the synthesis of the key fibrinolytic activator t-PA.

The group recently discovered that the main switch of this system is on the epigenetic level and involves histone modifications (acetylation) at critical points around the gene´s transcription start site. Since drugs are available that target this mechanism, current work is focused on the potential use of HDAC inhibitors as a novel clinical treatment to prevent atherothrombotic events. Research methods span from human and animal in vivo physiology to cellular and molecular biology including epigenetics.

 

Contact Information

Sverker Jern

The Wallenberg Laboratory, Sahlgrenska University Hospital, SE-413 45 Göteborg

Visiting Address:
Bruna Stråket 16

Phone:
+46 (0)31-343 5920

Page Manager: Anna Hallén|Last update: 3/10/2017
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