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Key publications

Original publications:

Wilhelmson AS, Fagman JB, Johansson I, Zou ZV, Andersson AG, Svedlund E, Johansson ME, Lindahl P, Fogelstrand P, Tivesten Å. Increased Intimal Hyperplasia Following Vascular Injury in Male Androgen Receptor Deficient Mice. Endocrinology. 2016 Aug 17:en20161100. [Epub ahead of print]. 

Nilton A, Sayin VI, Zou ZV, Sayin SI, Bondjers C, Gul N, Agren P, Fogelstrand P, Nilsson O, Bergo MO, Lindahl P. Targeting Zfp148 activates p53 and reduces tumor initiation in the gut. Oncotarget. 2016 Jul 28. doi: 10.18632/oncotarget.10899.

Le Gal K, Ibrahim MX, Wiel C, Sayin VI, Akula MK, Karlsson C, Dalin MG, Akyurek LM, Lindahl P, Nilsson J, Bergo MO. Antioxidants can increase melanoma metastasis in mice. Science translational medicine. 2015;7:308re308

Sayin VI, Khan O, Pehlivanoglu LE, Staffas A, Ibrahim MX, Asplund A, Ågren P, Nilton A, Bergström G, Bergö MO, Boren J, Lindahl P. Loss of One Copy of Zfp148 Reduces Lesional Macrophage Proliferation and Atherosclerosis in Mice by Activating p53. Circ Res. 2014 Oct 10;115(9):781-9. Epub 2014 Sep 11.

Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P*, Bergo MO*. Antioxidants accelerate lung cancer progression in mice. Science translational medicine. 2014;6:221ra215, *Corresponding authors.

Sayin VI, Nilton A, Ibrahim MX, Agren P, Larsson E, Petit MM, Hulten LM, Stahlman M, Johansson BR, Bergo MO, Lindahl P.
Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment. PloS one. 2013;8:e55720

Nilton A, Sayin VI, Staffas A, Larsson E, Rolf J, Petit MM, Palmqvist L, Swolin B, Cardell S, Lindahl P. Zinc finger protein 148 is dispensable for primitive and definitive hematopoiesis in mice. PloS one. 2013;8:e70022

Larsson, E., Wahlstrand, B., Hedblad, B., Hedner, T., Kjeldsen, S.E., Melander, O., Lindahl, P. Hypertension and Genetic Variation in Endothelial-Specific Genes (2013) PLoS ONE 8 (4) doi: 10.1371/journal.pone.0062035

Hagberg CE, Falkevall A, Wang X, Larsson E, Huusko J, Nilsson I, van Meeteren LA, Samen E, Lu L, Vanwildemeersch M, Klar J, Genove G, Pietras K, Stone-Elander S, Claesson-Welsh L, Yla-Herttuala S, Lindahl P, Eriksson U. Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature. 2010;464:917-21.1.

Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genove G, Arrondel C, Gerwins P, Kurschat C, Schermer B, Benzing T, Harvey SJ, *Kreuger J, *Lindahl P. Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1.*Equal contribution. Genome Med. 2009;1:108.

Mellberg S., Dimberg A., Bahram F., Hayashi M., Rennel E., Ameur A., Westholm J.O., Larsson E., Lindahl P., Cross M.J., Claesson-Welsh L. Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. FASEB J. 2009 Jan 9.

Petit M., Lindskog H., Larsson E., Wasteson P., Athley L., Breuer S., Angstenberger M., Hertfelder D., Mattsson E., Nordheim A., Nelander S., and Lindahl P. Smooth muscle expression of LPP is mediated by an alternative intronic promoter that is regulated by SRF/myocardin. Circ Res. 2008 May 29.

Larsson E., McLean S.E., Mecham R.P., Lindahl P., and Nelander S. Mutually exclusive gene modules define the diversity of smooth muscle. Mol Genet Genomics. 2008 May 29.

Wallgard E., Larsson E., He L., Hellström M., Armulik A., Nisancioglu M.H., Genove G., Lindahl P., and Betsholtz C. Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature. Arterioscler Thromb Vasc Biol. 2008 May 15.

Wasteson P., Johansson BR., Jukkola T., Breuer S., Akyürek LM., Partanen J., and Lindahl P. Developmental origin of smooth muscle cells in the descending aorta in mice. Development. 2008 May;135(10):1823-32. Epub 2008 Apr 16.

Larsson E, Lindahl P, Mostad P. HeliCis: a DNA motif discovery tool for colocalized motif pairs with periodic spacing. BMC Bioinformatics. 2007 Oct 28;8(1):418

Micke P, Kappert K, Ohshima M, Sundquist C, Scheidl S, Lindahl P, Heldin CH, Botling J, Ponten F, Ostman A. In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma. J Invest Dermatol. 2007 Jun;127(6):1516-23.

Cecilia Bondjers, Liqun He, Minoru Takemoto, Jenny Norlin, Noomi Asker, Mats Hellström, Per Lindahl and Christer Betsholtz. Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes. FASEB J. 2006 Aug;20(10):1703-5. Epub 2006 Jun 28.

Nystrom HC, Lindblom P, Wickman A, Andersson I, Norlin J, Faldt J, Lindahl P, Skott O, Bjarnegard M, Fitzgerald SM, Caidahl K, Gan LM, Betsholtz C, Bergstrom G. Plateletderived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries. Cardiovasc Res. 2006 Aug 1;71(3):557-65. Epub 2006 May 25.

Lindskog H, Athley E, Larsson E, Lundin S, Hellstrom M, and Lindahl P. New Insights to Vascular Smooth Muscle Cell and Pericyte Differentiation of Mouse Embryonic Stem Cells In Vitro. Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1457-64. 2006 (Apr 20 epub)

Tang J, Kozaki K, Farr AG, Martin PJ, Lindahl P, Betsholtz C, Raines EW. The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice. Am J Pathol. 2005 Sep;167(3):901-12.

Nelander S., Larsson E., Kristiansson E., Mostad P., Nerman O., Lindahl P. Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals. BMC Genomics. 2005 May 9;6(1):68.

Micke P., Bjørnsen T, Scheidl S., Demoulin S-D., Östman A., Ponten F., Bittinger F., Lindahl P#., and Busch C#. A fluid cover medium provides superior morphology and preserves RNA integrity in tissue sections for laser microbeam microdissection. J Pathol. 2004 Jan;202(1):130-8. #: These authors contributed equally to the manuscript.

Lindblom P., Gerhardt H., Liebner S., Abramsson A., Enge M., Hellstrom M., Backstrom G., Fredriksson S., Landegren U., Nystrom HC., Bergstrom G., Dejana E., Ostman A., Lindahl P., and Betsholtz C. Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev. 2003 Aug 1;17(15):1835-40.

Bondjers C., Kalén M., Hellström M., Scheidl S., Abramsson A., Renner O., Lindahl P., Hyeseon C., Kehrl J., and Betsholtz C. Transcription profiling of PDGF-B deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells. Am J Pathol. 2003 Mar;162(3):721-9.

Kozaki K., Kaminski W., Tang J., Hollenbach S., Lindahl P., Sullivan C., Yu J., Abe K., Martin P., Ross R., Betsholtz C., Giese N., and Raines E. Blockade of PDGF or its receptors appears to delay, but not prevent, fibrous cap formation in ApoE null mice, Am J Pathol. 2002 Oct;161(4):1395-407.

Scheidl S. J., Nilsson S., Takemoto M., Håkansson J., Kalén M., Hellström M., and Lindahl P. Gene expression analysis on laser microbeam microdissected cells from slender embryonic structures. Am J Pathol. 2002 March; 160(3):801-813

Chen JN, van Bebber F, Goldstein AM, Serluca FC, Jackson D, Childs S, Serbedzija G, Warren KS, Mably JD, Lindahl P, Mayer A, Haffter P, Fishman MC. Genetic steps to organ laterality in zebrafish. Comp Funct Genomics. 2001;2(2):60-8.

Buetow BS, Crosby JR, Kaminski WE, Ramachandran RK, Lindahl P, Martin P, Betsholtz C, Seifert RA, Raines EW, Bowen-Pope DF. Platelet-derived growth factor B-chain of hematopoietic origin is not necessary for granulation tissue formation and its absence enhances vascularization. Am J Pathol. 2001 Nov;159(5):1869-76.

Kaminski W., Lindahl P., Lin N. L., Broudy V. C., Crosby J. R., Hellström M., Swolin B., Bowen-Pope D. F., Martin P. J., Ross R., Betsholtz C., and Raines E.W. Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF b-receptor null mice. Blood. 2001 April;97, 1990-98.

Karlsson, L., Lindahl, P., Heath, J.K. and Betsholtz, C. PDGF-A control mesenchymal stem cells having a critical function in intestinal villus morphogenesis. Development. 2000 Aug;127, 3457-3466

Ohlsson, R., Falck, P., Hellström, M., Lindahl, P., Boström, H., Franklin, G., Ährlund- Richter, L., Pollard, J., Soriano, P., and Betsholtz, C. PDGF-B regulates the development of the labyrinthine layer of the mouse fetal placenta. Dev. Biol. 1999 Aug;212, 124-136,

Hellström M, Kalén M, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFRbeta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development. 1999 Jun;126(14):3047-55.

Lindahl, P., Hellström, M., Kalén, M., Karlsson, L., Pekny, M., Pekna, M., Soriano, P., and Betsholtz, C. Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development. 1998 Sep;125, 3313-3322.

Lindahl, P., Johansson, B, R., Levéen, P., and Betsholtz, C. Pericyte loss and micro-aneurysm formation in platelet-derived growth factor B-chain-deficient mice. Science. 1997 Jul;277, 242-245.

Lindahl, P., Karlsson, L., Hellström, M., Gebre-Medhin, S., Willetts, K., Heath, J, K., and Betsholtz, C. Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development. 1997 Oct;124, 3943-3953

Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., Nilsson, M., Kurland, S., Törnell, J., Heath, j. K. and Betsholtz, C. PDGF-A sagnaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell. 1996 Jun;85, 863-873,

Yacob, A., Lindahl, P., Rubin, K., Wendel, M., Heinegård, D., Rydén,C. Purification of a bone sialoprotein-binding protein from Staphylococcus aureus. Eur. J. Biochemi. 1994 Jun 15;222, 919-925.

Tingstrom A, Reuterdahl C, Lindahl P, Heldin CH, and Rubin K. Expression of platelet-derived growth factor-beta receptors on human fibroblasts. Regulation by recombinant platelet-derived growth factor-BB, IL-1, and tumor necrosis factor-alpha. J Immunol. 1992 Jan 15;148(2):546-54.

Review articles and book chapters:

Betsholtz C., Lindblom P., Bjarnegård M., Enge M., Gerhardt H., and Lindahl P. Role of plateletderived growth factor in mesangium development and vasculopathies: lessons from plateletderived growth factor and platelet-derived growth factor receptor mutations in mice. Current Opinion in Nephrology and Hypertension. 2004 Jan;13:45-52

Betsholtz C, Karlsson L, Lindahl P. Developmental roles of platelet-derived growth factors. Bioessays. 2001 Jun;23(6):494-507.

Betsholtz, C., Karlsson, L., and Lindahl, P. Developmental roles of platelet-derived growth factors. BioEssays. 2001 Jun;23:494-507 Lindahl, P., Boström, H., Karlsson, L., Hellström, M., Kalén, M.,and Betsholtz, C. Role of platelet-derived growth factors in angiogenesis and alveogenesis. Current topics in Pathology. 1999;93:27-33.

Lindahl, P., Hellström, M., Kalén, M., and Betsholtz, C. Endothelial - perivascular cell signaling in vascular development: lessons from knockout mice. Current Opinion in Lipidology. 1998 Oct;9(5):407-411.

Lindahl, P. and Betsholtz, C. Not all myofibroblasts are alike or Revisiting the role of PDGF-AA and PDGF-BB using PDGF targeted mice. Current Opinion in Nephrology and Hypertension. 1998 Jan;7:21-26






Complete list of publications

See all publications (GUP)

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