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Main research

Oxidative stress and the subsequent damage to proteins, lipids and DNA play a significant role in age-related disorders such as cancer and atherosclerosis. The impact of oxidative damage on basal cellular functions including cell division and growth is often determined by the tumor suppressor p53. Understanding the regulation of tumor suppressor functions under oxidative conditions could therefore open up new therapeutic opportunities in cardiovascular disease and cancer.

Lindahl and his group recently discovered that the transcription factor Zinc finger protein 148 (Zfp148) is a major regulator of p53 under oxidative conditions, and their program is devoted to exploring this finding and its implications for cardiovascular disease and cancer. They also discovered that dietary antioxidants, by reducing DNA damage and p53 activity, accelerate the progression of lung tumors in mice and the growth of human lung cancer cells in culture. Another research focus is therefore to explore the controversial role of antioxidants in cancer.

The research group conducts translational studies using the mouse as their primary model system, but also investigates patient material in collaboration with clinical investigators.

Contact Information

Per Lindahl

Wallenberg Laboratory, SU/Sahlgrenska, SE-413 45 Göteborg, Sweden

Visiting Address:
Bruna Stråket 16

Page Manager: Anna Hallén|Last update: 10/12/2015
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