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Main research

My research is focused on the human genetics of lipids and insulin resistance. At the University of Texas Southwestern Medical Center, I used a resequencing approach to show how common and rare mutations in angiopoietin-like proteins affect the metabolism of circulating triglycerides. I also performed a genome wide association study on the Dallas Heart Study population, which identified the patatin-like phospholipase domain-containing 3 (PNPLA3) I148M mutation as a determinant of hepatic steatosis. To date, this is the most widely replicated genetic mutation associated with this condition.

Together with my colleagues at the University of Cambridge, UK, I observed that the PNPLA3 148M mutation is associated with elevated transaminase levels (an index of hepatic damage) in obese adult and children but not in normal weight individuals. These findings suggest that obesity modulates signals arising from the genome, and indicate that the obese state is necessary to study traits highly correlated with obesity.

My research group at the Wallenberg Laboratory focuses on the role of genetic variants in modulating metabolic traits such as serum lipid levels, insulin resistance and liver fat accumulation. Our research field ranges from genetic association studies in large cohorts (including the Swedish Obese Subjects cohort) to molecular genetics of human mutations.

 

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Sterfano Romeo

Contact Information

Stefano Romeo

The Wallenberg Laboratory, Sahlgrenska University Hospital, SE-413 45 Göteborg

Visiting Address:
Bruna Stråket 16

Phone:
+46 (0)31-342 6735

Page Manager: Anna Hallén|Last update: 1/28/2013
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