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Main research

Cardiovascular disease (CVD) is the leading cause of death in Sweden and globally. Atherosclerosis is the most important underlying mechanism for ischemic heart disease, the major form of CVD. A smaller, but clinically important, type of CVD is abdominal aortic aneurysms (AAAs).

An AAA is a pathological widening of the abdominal aorta, which in many cases remains asymptomatic but may result in a life-threatening sudden rupture of the aortic wall. Although certain risk factors are shared between atherosclerotic cardiovascular disease and AAAs, these clearly represent two distinct vascular diseases.

Since a few years back, all Swedish men, but not women, are offered an ultrasound screening for AAA at 65 years of age. There is a strong male preponderance in both atherosclerosis-based CVD and AAAs, but the actions of sex steroids in these diseases are poorly defined.

The overall aim of our research is to determine the role of androgens (“male” sex steroids, e.g. testosterone) in atherosclerotic CVD and AAAs. In our research, we combine epidemiology with studies in genetically manipulated mice to answer questions concerning the cardiovascular actions of sex steroids.

Contact Information

Åsa Tivesten

The Wallenberg Laboratory, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden

Visiting Address:
Bruna Stråket 16

Phone:
+46 (0)31-342 2913

Fax:
+46 (0)31-82 37 62

Page Manager: Anna Hallén|Last update: 9/12/2014
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